Diltiazem-tetraiodide bismuthate (III) based PVC membrane for selective determination of diltiazem hydrochloride

A new coated-wire electrode based on PVC membrane plasticized with dioctyl phthalate (DOP) and containing the diltiazem-tetraiodido bismuthate (III) ion association coated a silver wire was constructed used for potentiometric determination of diltiazem hydrochloride. The performance characterized optimized according to following experimental criteria: composition, soaking time, working pH range, response time. interference caused by different species investigated as well. best composition found be 49.75% DOP, 0.5% pair. This sensor showed linear good Nernstian slope 57.60±1.38 mV/decade over concentration range5.0×10-5 – 2.50×10-2 M, detection limit 2.88×10-5 it usable within wide range 2.5–8.0. fast time (18 sec), relative long lifetime (2.4 months, 2 h day). isothermal coefficient (dE°/dT) calculated 5.36×10-4 V/℃ 20 80℃, which exhibits thermal stability. coted-wire successfully applied hydrochloride both in pure form pharmaceutical preparations. dissolution test drug carried out